Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

In the present study, various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy LC-MS spectrometry, besides elemental analysis. The compounds evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small lung cancer), MCF-7 (breast HT-29 (colorectal adenocarcinoma PC-3 (androgen-independent prostate adenocarcinoma), Hep3B (hepatocellular carcinoma HeLa (epitheloid cervix cancer). Among all target compounds, 4g 4h exhibited more promising on lines (IC50 = 17.8 μM 21.2 μM, respectively) with high selectivity. Further mechanistic studies proposed that induced apoptosis is mediated through intrinsic apoptotic pathway changes in mitochondrial membrane potential finally activating caspase-9 caspase-3. results have been encouraging enough to merit further investigation.